将肿瘤细胞接种于裸鼠脾脏，通过观察裸鼠体内肿瘤的形成情况，从而评价出细胞的转移能力；常用于肿瘤细胞肝转移能力的检测。

通过外科手术，将肿瘤细胞注射到动物脾脏中，制备脾脏接种转移模型，通过借助小动物活体成像仪器观察动物体内转移灶的发生、发展情况，评价细胞在动物体内的转移能力，主要转移器官为肝脏，主要适用于肿瘤在动物肝部、肠系膜、全身性转移方向的研究。可提供的建模细胞系有：肝癌、结肠癌、胃癌等。

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