基因下游机制研究

通过组学实验方法分析目的基因对下游信号通路的影响,再利用慢病毒介导的高内涵基因功能筛选平台寻找下游通路起到关键作用的基因,最终通过更多的体内体外实验验证其调控调控作用,从而寻找并验证目的基因到下游的信号轴。

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参考文献REFERENCE

Wang Y, Chen D, Qian H, et al. The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression[J]. Cancer Cell, 2014, 26(3): 374-389.

Kabbout M, Garcia M M, Fujimoto J, et al. ETS2 Mediated Tumor Suppressive Function and MET Oncogene Inhibition in Human Non–Small Cell Lung Cancer[J]. Clinical Cancer Research, 2013, 19(13): 3383-3395.

Jan Y, Tsai H, Yang C, et al. Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3[J]. Cancer Research, 2012, 72(19): 5119-5129.

Wang C, Jedlicka P, Patrick A N, et al. SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer[J]. Journal of Clinical Investigation, 2012, 122(5): 1895-1906.